Diferencias de género en percepciones sobre violencia sexual, igualdad y agresiones sexuales facilitadas por drogas en ocio nocturno / Gender-based differences in perceptions about sexual violence, equality and drug-facilitated sexual assaults in nightlife contexts

La violencia sexual, incluyendo las agresiones sexuales facilitadas pordrogas, es un serio problema cada vez más común en los contextos de ocionocturno. Este trabajo estudia las actitudes y percepciones de la juventudespañola en torno a la violencia sexual en dicho ámbito. Los participantesse reclutaron mediante muestreo en bola de nieve. Se realizó un análisisbivariado para identificar posibles factores sociodemográficos y de ocionocturno relacionados con género. La significación estadística de lasdiferencias entre estas variables se evaluó mediante las pruebas de chicuadrado y exacta de Fisher. Las mujeres percibieron un menor nivelde seguridad personal, así como la existencia de percepciones socialesque penalizan en mayor medida el consumo de drogas femenino que elmasculino, y que culpabilizan a las mujeres por la violencia que sufren.Además, ellos mostraron mayor disposición a mantener relaciones sexualescon personas incapaces de otorgar su consentimiento debido a los efectosde las drogas. Los hombres creen en mayor medida que las agresionessexuales ocurren debido al uso de alcohol u otras drogas por parte delas víctimas. En el contexto de ocio nocturno, las mujeres son propensasa percibir la existencia de una falta de apoyo social hacia ellas, así comoun sentimiento de impunidad social hacia los agresores. Además, existennumerosas concepciones erróneas en torno a las agresiones sexualesfacilitadas por drogas. La mayoría cree que las agresiones ocurren trasla administración encubierta de sustancias a la víctima por parte de unagresor desconocido. Además, se subestimó la participación del alcohol.Nuestros hallazgos son útiles para diseñar esfuerzos preventivos biendirigidos, desmitificar el fenómeno de las agresiones sexuales facilitadaspor drogas y mejorar el apoyo social a las víctimas. (AU)

Sexual violence, including drug-facilitated sexual assaults, is a seriousissue that is becoming increasingly common in leisure nightlife contexts.This study provides information about the attitudes and perceptionsof Spanish youths towards sexual violence within that setting. Theparticipants were recruited by a snowball sampling scheme. A bivariateanalysis was performed to identify possible sociodemographic andnightlife recreational habit factors related to gender. The statisticalsignificance of the differences between the studied variables was assessedusing the chi-squared and Fisher’s exact tests. Women perceived a lowlevel of personal security, as well as the existence of social perceptionspenalizing female more than male drug use, and blaming women for thesexual violence they suffer. Women also recognised less explicit violentbehaviours as violence significantly more than men did. Men were morewilling to have sexual intercourse with someone unable to expressconsent because of drugs. In addition, they believed more strongly thatsexual assaults take place because of the victim’s use of alcohol or otherdrugs. In a leisure nightlife context, women are prone to perceive alack of social support for themselves and the feeling of impunity for theperpetrators. Furthermore, numerous misconceptions surround drugfacilitated sexual assaults, with the majority of respondents believingthat assaults happen after the surreptitious administration of substancesto the victim by an unknown assailant. Moreover, the involvement ofalcohol was underestimated. Our findings are useful for designingprevention efforts, demystifying the drug-facilitated sexual assaults andenhancing social support for victims. (AU)

Novel Adenosine Analog, N6-(4-Hydroxybenzyl)-Adenosine, Dampens Alcohol Drinking and Seeking Behaviors.

Adenosine signaling is associated with ethanol-related behaviors. We previously found that adenosine A2A receptor (A2AR) activation dampens ethanol drinking behaviors in equilibrative nucleoside transporter 1 (ENT1) knockout mice, and A2AR inhibition augments reward-seeking behavior in wild-type mice. The novel adenosine analog N6-(4-hydroxybenzyl)-adenosine (NHBA), which is isolated from the rhizomes of Gastrodia elata, activates A2AR and inhibits ENT1. Here, we examined the effects of NHBA on ethanol drinking in the two-bottle choice test and operant ethanol seeking behaviors. We selected mice exhibiting high ethanol drinking behavior in the two-bottle choice test. NHBA (0.1 mg/kg, i.p.) reduced ethanol drinking behavior in a limited-access 3-hour drinking session in high-consumption ethanol drinking mice, and NHBA (0.1 mg/kg, i.p.) did not alter locomotor activity in the open-field test. Operant conditioning with 10% ethanol and 10% sucrose (10E10S) reward increased zone entries and time spent in the ethanol zone, while NHBA (0.1 mg/kg, i.p.) dampened ethanol zone preference in the Y-maze. Furthermore, NHBA (0.1 mg/kg, i.p.) devalued 10E10S and 10% ethanol (10E) reward after operant conditioning with 10E10S and 10E. Taken together, NHBA through A2AR activation and ENT1 modulation may dampen ethanol drinking and seeking behaviors, suggesting that NHBA is a potential therapeutic agent for treating alcohol use disorder. SIGNIFICANCE STATEMENT: Our work highlights that A2AR activation and ENT1 inhibition by a novel adenosine analog isolated from Gastrodia elata, N6-(4-hydroxybenzyl)-adenosine, decreases ethanol drinking and seeking behaviors. We suggest that NHBA is a potential therapeutic agent to treat alcohol use disorder.

Social modulation of drug use and drug addiction.

This review aims to demonstrate how social science and behavioral neurosciences have highlighted the influence of social interactions on drug use in animal models. In neurosciences, the effect of global social context that are distal from drug use has been widely studied. For human and other social animals such as monkeys and rodents, positive social interactions are rewarding, can overcome drug reward and, in all, protect from drug use. In contrast, as other types of stress, negative social experiences facilitate the development and maintenance of drug abuse. However, interest recently emerged in the effect of so-called "proximal" social factors, that is, social interactions during drug-taking. These recent studies have characterized the role of the drug considered, the sharing of drug experience and the familiarity of the peer which interaction are made with. We also examine the few studies regarding the sensorial mediator of social behaviors and critically review the neural mediation of social factors on drug use. However, despite considerable characterization of the factors modulating distal influences, the mechanisms for proximal influences on drug use remain largely unknown. This article is part of the Special Issue entitled 'The neuropharmacology of social behavior: from bench to bedside'.

Modeling Relapse to Pavlovian Alcohol-Seeking in Rats Using Reinstatement and Spontaneous Recovery Paradigms.

BACKGROUND: Animal models are critical for studying causal explanations of relapse. Using a Pavlovian conditioning procedure with alcohol, we examined relapse after extinction triggered by either re-exposure to alcohol (reinstatement) or a delay between extinction and test (spontaneous recovery). METHODS: Male, Long-Evans rats were acclimated to 15% alcohol in the home-cage using an intermittent-access 2-bottle choice procedure. Next, they received Pavlovian conditioning sessions in which an auditory-conditioned stimulus (CS; 20 second white noise; 8 trials/session; variable time 240 seconds) was paired with 15% alcohol (0.3 ml/CS; 2.4 ml/session) that was delivered into a fluid port for oral ingestion. In subsequent extinction and test sessions, CS presentations occurred as before, but without alcohol. RESULTS: In experiment 1, exposure to either alcohol or water in the fluid port following extinction reinstated CS-elicited port entries at test 24 hours later. In a follow-up study using the same procedure (experiment 2), reinstatement was more robustly stimulated by alcohol, compared to a familiar lemon-flavored liquid. In experiment 3, systemic alcohol injections (0, 0.5, or 1.0 g/kg, intraperitoneal) administered either 24 hours or 15 minutes before test did not reinstate CS-elicited alcohol-seeking. Importantly, enzymatic assays in experiment 4 revealed detectable levels of alcohol in the blood following oral alcohol intake or intraperitoneal injection, suggesting that a pharmacological effect was likely with either route of administration. Last, in experiment 5, a 23-day delay between extinction and test resulted in a robust spontaneous recovery of CS-elicited alcohol-seeking. CONCLUSIONS: The reinstatement and spontaneous recovery effects revealed herein provide evidence of viable new behavioral paradigms for testing interventions against relapse.

Análisis de aguas residuales con fines epidemiológicos: aplicaciones a la estimación del consumo de sustancias de abuso y en salud pública en general. Red española ESAR-Net / Wastewater-based epidemiology: applications towards the estimation of drugs of abuse consumption and public health in general. The Spanish network ESAR-Net

En este artículo se presenta la metodología de análisis de aguas residuales con fines epidemiológicos (wastewater-based epidemiology, WBE) y su potencial para abordar diversos aspectos relacionados con la salud pública. Esta metodología permite obtener datos a una escala temporal y espacial relativamente pequeña (típicamente datos diarios-semanales sobre un municipio) de hábitos de consumo de sustancias de abuso, ilegales (como la cocaína o el cannabis) o legales (como el alcohol) a través de la determinación de biomarcadores de consumo (el compuesto original no metabolizado o alguno de sus metabolitos) en el agua residual. Aparte de discutir los fundamentos, ventajas y limitaciones de WBE, se comentan los precedentes más relevantes a nivel internacional, y las actividades más destacables en España en este ámbito. Finalmente, se exponen, los objetivos de la Red Española de Análisis de Aguas Residuales con Fines Epidemiológicos (ESAR-Net), una "Red de Excelencia " que agrupa a investigadores españoles con amplia experiencia en el área de WBE, así como las perspectivas de futuro de esta metodología puede tener para mejorar las competencias de la Salud Pública en España

This manuscript introduces Wastewater-Based Epidemiology (WBE) and its potential in the assessment of diverse aspects related to public health. This methodology can provide data in a relatively short temporal and local scale (typically dialy-weekly at the municipal level) on consumption patterns of illicit drugs (e.g. cocaine or cannabis), licit substances of abuse (e.g. alcohol) by measuring their consumption biomarkers (i.e. the original unmetabolized substance or some of its metabolite) in wastewater. Besides discussing the fundaments, advantages and shortcomings of WBE, it reviews some of the main precedents at international level and most remarkable activities that have been taken place in this field in Spain. Finally, the Spanish Network of Wastewater-Based Epidemiology (ESAR-Net) as is presented. ESAR-Net is an Excellence Network that sums up the efforts of the most relevant Spanish researchers in the field of WBE, aiming to investigate future perspectives of this methodology and its impact on Public Health competences in Spain

External-cause mortality among adolescents and young adults in Greece over the millennium's first decade 2000-09.

BACKGROUND: Several important socio-behavioral public health problems that either peak or start during the second decade of life contribute to young people's mortality. The aim of this study was to explore patterns, rates, trends and regional variations of external-cause (due to environmental events/circumstances) mortality among young people aged 10-24 years in Greece, over the decade 2000-09. METHODS: Data were electronically derived from the database of the Hellenic Statistical Authority to study general and specific mortality rates by major causes of death. RESULTS: Road traffic crashes (RTCs), illicit drug use and suicide accounted for 65.8, 14.7 and 4.8%, of total external-cause mortality, respectively. Mortality rates (deaths per 100 000) did not exhibit intra-country variability, were higher in young adults than in adolescents, in males than in females and decreased by 39%, from 33.6 in 2000 to 20.4 in 2009 (P < 0.001), due to declines in mortality from RTCs (from 21.3 to 14.3; P = 0.001), substance abuse (from 5.1 to 2.1; P = 0.003) and suicides (from 2.0 to 0.9; P = 0.003). CONCLUSIONS: External causes of young people's mortality were mainly psychosocial and behavioral in origin. Despite improvement over the decade, young people in Greece still have unmet health-care needs and may further benefit from a multipronged public health approach through improved youth-friendly health services.

The North Carolina Controlled Substances Reporting System: a valuable tool for combating prescription drug misuse.

Prescription drug misuse is a growing problem that is resulting in increased morbidity and mortality throughout the United States. The North Carolina Controlled Substances Reporting System has proven to be an effective tool that allows health care providers to make more informed decisions when they prescribe or dispense controlled substances.

Perfil de consumo de substâncias psicoativas por adolescentes escolares do ensino fundamental da Grande Porto Alegre/RS / Profile of consumption of psychoative substances in teens students of elementary school from the Great Porto Alegre/RS

Este trabalho objetivou avaliar o perfil de consumo de substâncias psicoativas por escolares da Grande Porto Alegre/RS. Método: Estudo transversal com amostra composta por adolescentes de ambos os sexos (n=147). Para coleta dos dados utilizou-se questionário elaborado para tal. Resultados: A experimentação do álcool ocorreu em média aos 11,48 anos (DP=1,82). As substâncias mais utilizadas na vida foram: álcool por 80% (DP=54,4) da amostra, tabaco por 14% (DP=9,5) e maconha por 3% (DP=2,0). Evidenciou-se associação entre percepção sobre problemas com álcool e: problemas com tabaco (p<0,001), com maconha (p=0,041) e com anabolizantes (p=0,008). Conclusão: A amostra apresentou uso precoce de álcool e associação entre a percepção de problemas decorrentes do álcool e problemas com: tabaco, maconha e anabolizantes (AU)

This study aimed to evalute the profile of psychoactive substances consumption by students of PortoAlegre/RS. Method: Cross-sectional study with a sample of adolescents of both sexes (n=147). For data collection we used questionnaire prepared for that. Results: The trial of alcohol occurred on average at 11.48 years (SD = 1.82). The substance most commonly used in life were: alcohol by 80% (SD = 54.4) of the sample, tobacco by 14% (SD = 9.5) and cannabis by 3% (SD = 2.0). Associations were observed between the perceptions about problems with alcohol and: problems with tobacco use(p <0.001), problems with marijuana (p = 0.041) and problems with steroids (p = 0.008). Conclusion: The sample showed early alcohol use and association between the perception of problems related toalcohol and have problems with: tobacco, marijuana and anabolic steroids (AU)

Perfil de consumo de substâncias psicoativas por adolescentes escolares do ensino fundamental da Grande Porto Alegre/RS / Profile of consumption of psychoative substances in teens students of elementary school from the Great Porto Alegre/RS

Este trabalho objetivou avaliar o perfil de consumo de substâncias psicoativas por escolares da Grande Porto Alegre/RS. Método: Estudo transversal com amostra composta por adolescentes de ambos os sexos (n=147). Para coleta dos dados utilizou-se questionário elaborado para tal. Resultados: A experimentação do álcool ocorreu em média aos 11,48 anos (DP=1,82). As substâncias mais utilizadas na vida foram: álcool por 80% (DP=54,4) da amostra, tabaco por 14% (DP=9,5) e maconha por 3% (DP=2,0). Evidenciou-se associação entre percepção sobre problemas com álcool e: problemas com tabaco (p<0,001), com maconha (p=0,041) e com anabolizantes (p=0,008). Conclusão: A amostra apresentou uso precoce de álcool e associação entre a percepção de problemas decorrentes do álcool e problemas com: tabaco, maconha e anabolizantes

This study aimed to evalute the profile of psychoactive substances consumption by students of PortoAlegre/RS. Method: Cross-sectional study with a sample of adolescents of both sexes (n=147). For data collection we used questionnaire prepared for that. Results: The trial of alcohol occurred on average at 11.48 years (SD = 1.82). The substance most commonly used in life were: alcohol by 80% (SD = 54.4) of the sample, tobacco by 14% (SD = 9.5) and cannabis by 3% (SD = 2.0). Associations were observed between the perceptions about problems with alcohol and: problems with tobacco use(p <0.001), problems with marijuana (p = 0.041) and problems with steroids (p = 0.008). Conclusion: The sample showed early alcohol use and association between the perception of problems related toalcohol and have problems with: tobacco, marijuana and anabolic steroids